Advanced glycation in diabetes, aging and age-related diseases: conclusions
نویسندگان
چکیده
منابع مشابه
Aging, Obesity, and Inflammatory Age-Related Diseases
The increase in the prevalence of obesity represents a worldwide phenomenon in all age groups and is pathologically and genetically correlated with several metabolic and cardiovascular diseases, representing the most frequent age-related diseases. Obesity superimposed on aging drastically increases chronic low-grade inflammation (inflammaging), which is an important link between obesity, insuli...
متن کاملProtein glycation, diabetes, and aging.
Biological amines react with reducing sugars to form a complex family of rearranged and dehydrated covalent adducts that are often yellow-brown and/or fluorescent and include many cross-linked structures. Food chemists have long studied this process as a source of flavor, color, and texture changes in cooked, processed, and stored foods. During the 1970s and 1980s, it was realized that this pro...
متن کاملAdvanced glycation end products in age-related macular degeneration.
OBJECTIVE To investigate the localization of N epsilon-(carboxymethyl)lysine (CML), a component and major immunologic epitope of advanced glycation end products, in aged eyes and choroidal neovascular membranes (CNVMs) surgically excised from eyes with age-related macular degeneration. METHODS Immunohistochemistry for CML was performed using 8 snap-frozen, surgically excised CNVMs. Twelve eye...
متن کاملDietary Advanced Glycation End Products and Aging
Advanced glycation end products (AGEs) are a heterogeneous, complex group of compounds that are formed when reducing sugar reacts in a non-enzymatic way with amino acids in proteins and other macromolecules. This occurs both exogenously (in food) and endogenously (in humans) with greater concentrations found in older adults. While higher AGEs occur in both healthy older adults and those with ch...
متن کاملNeuronal and microglial cathepsins in aging and age-related diseases.
It has been long believed that cathepsins compensate for each other because of their overlapping substrate specificities. However, there is increasing evidence that disturbance of the normal balance of their enzymatic activities is the first insult in brain aging and age-related diseases. The imbalance of cathepsins may further cause age-related neuropathological changes such as accumulation of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Glycoconjugate Journal
سال: 2016
ISSN: 0282-0080,1573-4986
DOI: 10.1007/s10719-016-9711-1